The conformation of influenza virus haemagglutinin
نویسندگان
چکیده
منابع مشابه
Antigenic Variation of the Haemagglutinin Gene of the Influenza A (H1N1) pdm09 Virus Circulating in Shiraz, February-April 2013
Background: A new pandemic influenza A (H1N1) emerged in April 2009, causing considerable morbidity and mortality. Since mutations in the haemagglutinin (HA) may influence the antigenicity and pathogenicity of the virus, continued epidemiological and molecular characterization for the effective control of pandemic flu and developing of more appropriate vaccine is crucial. Objective: To monitor ...
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There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 sw...
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The structure of the haemagglutinin-esterase-fusion (HEF) glycoprotein from influenza C virus has been determined to 3.2 A resolution by X-ray crystallography. A synthetic mercury-containing esterase inhibitor and receptor analogue, 9-acetamidosialic acid alpha-thiomethylmercuryglycoside, was designed as the single isomorphous heavy-atom derivative. The asymmetric unit of one crystal form (form...
متن کاملThe structure and role of the carbohydrate moieties of influenza virus haemagglutinin.
The haemagglutinin glycoprotein is the major surface antigen of influenza virus and is responsible for receptor binding, membrane fusion and antigenic variation. The 1968 Hong Kong haemagglutinin contains seven Asn-Xaa-Ser/Thr sequences, all of which are glycosylated (1 3 000daltons of carbohydrate per monomer, 20% carbohydrate by wt.). The three-dimensional structure of the haemagglutinin (Wil...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1977
ISSN: 0014-5793
DOI: 10.1016/0014-5793(77)80406-7